The invention relates to a series of pyrrolopyrimidinone derivatives of the formula
(1):
##STR1##
- wherein R1 is H; C1-C3 alkyl optionally
substituted with one or more fluoro atoms; or C3-C6 cycloalkyl;
- R2 is H; a halogen atom; C1-C6 alkyl
optionally substituted with OH, C1-C3 alkoxy, C3-C6
cycloalkyl, or with one or more fluoro atoms; C3-C6 cycloalkyl;
C2-C6 alkenyl; or C2-C6 alkynyl;
- R3 is H; C1-C6 alkyl optionally substituted
with OH, C1-C3 alkoxy, C3-C6 cycloalkyl,
or with one or more fluoro atoms; C3-C6 cycloalkyl; C2-C6
alkenyl; or C2-C6 alkynyl;
- R4 is C1-C6 alkyl optionally substituted
with C3-C6 cycloalkyl or with one or more fluoro atoms; C2-C6
alkenyl; C2-C6 alkynyl; or C3-C6 cycloalkyl; and
- R5 is SO2NR6R7; NHSO2NR6R7;
NHCOCONR6R7; NHSO2R8; NHCOR8;
or phenyl or heterocyclyl either of which is optionally substituted with
one or more fluoro atoms or C1-C3 alkyl.
|
|
|
