The present invention provides a liposomal composition for targeted delivery of drugs. The composition comprises large unilamellar vesicles (LUV) encapsulating poloxamers and one or more delivery agents. The composition and concentration of the poloxamer inside the LUVs is such that upon heating to temperatures above the critical micellar temperature of the poloxamer, the LUVs becomes leaky causing release of the encapsulated drug. The present invention also provides a method for delivery of agents to targeted sites and a method for preparing the LUVs suitable for use according to the method described herein.