The present invention relates to a polynucleotide comprising a ubiquitous chromatin opening element (UCOE) which is not derived from 13. The present invention also relates to a vector comprising the polynucleotide sequence, a host cell comprising the vector, use of the polynucleoticle, vector or host cell in therapy and in an assay, and a method of identifying UCOEs. The UCOE opens chromatin or maintains chromatin in an open state and facilitates reproducible expression of an operably-linked gene in cells of at least two different tissue types.

 
Web www.patentalert.com

< Polypeptides of the "basic helix-loop-helix" bHLH family, corresponding nucleic acid sequences

< N-acylphosphoramidites and their use in oligonucleotide synthesis

> Hybrid maize plant and seed 30A29

> Flint polypeptide analogs

~ 00220