A medical device such as a coronary stent is provided that can be visualized in-vivo while further aiding in the prevention of restenosis. The medical device comprises a core having a first layer disposed thereon. The first layer is made from a material that is radio-opaque so that the medical device may be visualized in-vivo. An outer layer is disposed onto and surrounds at least a portion of the first layer to provide a barrier layer between the radio-opaque inner layer and blood and/or tissue disposed within the patient's vessel. The outer surface of the outer layer may include a textured surface of micro-pores, grooves, cross-hatched lines to receive a therapeutic agent. Drugs and treatments which utilize anti-thombogenic agents, and anti-proliferation agents may be readily deployed from the textured outer surface of the outer layer of the medical device.