A modified release preparation having one or more coated core elements, each core element including an active ingredient and having a modified release coating, wherein a stabilising coat is provided between each core element and its modified release coating so that, upon in vitro dissolution testing, the amount of active ingredient released at any time on a post-storage dissolution profile is within 40 percentage points of the amount of active ingredient released at any time on a pre-storage dissolution profile.

 
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> Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds

> Packaging cells comprising codon-optimized gagpol sequences and lacking lentiviral accessory proteins
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