The invention concerns coated particles based on granulated microcrystals of
ibuprofen, its pharmaceutically acceptable isomers and salts, characterized in
that they comprise a coating obtained in a fluidized bed apparatus with a hydroalcoholic
dispersion consisting of a mixture comprising (A) 5 to 50% by weight of ethylcellulose
relative to ibuprofen; (B) 10 to 60% by weight of hydroxypeopylmethylcellulose
relative to the ethylcellulose; and (C) 1 to 40% by weight of silica with antistatic
and permeabilizing properties relative to the ethylcellulose, the resulting coating,
whereof at least one of the constituents can be used for granulating the ibuprofen
microcrystals resulting in said particles, thereby masking the unpleasant taste
of ibuprofen and significantly reducing its irritating effect on the throat after
deglutition and substantially immediate release of ibuprofen when the particles
are placed in an aqueous medium.