A programmable internal combustion engine, comprising programmable computer processor controlled engine components including electronically controllable valves, fuel injection and air fuel mixture ignition cylinder components, is programmed to dynamically reconfigure an internal combustion engine to run on a range of combustible fuels. Cylinder independent ignition test modes using Spark Ignition, Homogeneous Charge Compression Ignition and Compression Ignition are performed to determine the best ignition mode and cylinder component states for combusting a given fuel. In situ real-time testing of a given fuel yield results for a dynamic reconfiguration of individual component states providing an engine which can run on a range of combustible fuels and fuel blends.