A flexible clip applier includes a flat wire wound tubular coil, a pair of jaws at the end of the coil, end effector wires extending through the coil and coupled to the jaws, and a clip-advancing wire extending through the coil. A proximal handle is adapted to impart tensile force the end effector wires and the tubular coil, and compressive force to the clip-advancing wire and tubular coil to thereby effect advancement of a clip into the jaws and over tissue compressed between the jaws, and deformation of the clip over the tissue.