This invention provides PAI-1 inhibiting compounds of Formula I: ##STR1##

wherein: R₁, R₂, R₃, and R₄ are each H, alkyl, alkanoyl, halo, OH, aryl optionally substituted with R₈, perfluoroalkyl, alkoxy, amino, alkylamino, dialkylamino, perfluoroalkoxy; R₅ is H, alkyl, perfluoroalkyl, aryl optionally substituted with R₈, alkanoyl, aroyl optionally substituted with R₈; R₆ is H, alkyl, alkylaryl, benzyl optionally substituted with R₈, alkanoyl, aroyl optionally substituted with R₈; R₇ is H, alkyl, alkylaryl, aryl optionally substituted with R₈; n is 0-6; A is COOH, or an acid mimic such as tetraazole, SO₃H, PO₃H₂, tetronic acid, etc.; R₈ is H, alkyl, cycloalkyl, alkanoyl, halo, OH, perfluoroalkyl, alkoxy, amino, alkylamino, dialkylamino, perfluoroalkoxy; or a pharmaceutically acceptable salt thereof; as well as pharmaceutical compositions and methods of treatment using these compounds.