A specially arranged vacuum loader and industrial dust collector with a perforated plate tangential cyclone separator is provided to efficiently remove, readily collect, effectively separate and safely dispose of wet, dry and fibrous materials, including liquids and slurries. The special vacuum loader and industrial dust collector has a solids-gas separation compartment comprising a tangential cyclone separator, preferably a perforated plate tangential separator, which is positioned generally alongside and laterally offset from one or more filtering compartments to minimize turbulence and re-entrainment of the collected particulate material.