3-Substituted quinuclidines and their use

   
   

This invention relates to novel 3-substituted quinuclidine derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neurodegeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

 
Web www.patentalert.com

< Use of compounds that are effective as selective opiate receptor modulators

< Modulators of glucocorticoid receptor, AP-1, and/or NF-kB activity and use thereof

> 7-sulfonyl-3-benzazepine derivatives as modulators of the dopamine receptor and their use for the treatment cns disorders

> 2,3-Oxidosqualene-lanosterol cyclase inhibitors

~ 00199