The present invention is directed to drug dosage forms that release an agent
that raises the pH of a patient's gastrointestinal tract, followed by a non-steroidal
anti-inflammatory drug. The dosage form is designed so that the NSAID is not released
until the intragastric pH has been raised to a safe level. The invention also encompasses
methods of treating patients by administering this coordinated release, gastroprotective,
antiarthritic/analgesic combination unit dosage form to achieve pain and symptom
relief with a reduced risk of developing gastrointestinal damage such as ulcers,
erosions and hemorrhages.
