The present invention relates to aromatic guanylhydrazone compounds and
their use as pharmaceutically active agents, especially for prophylaxis
and treatment of virally caused diseases and infections, including
opportunistic infections. The inventive guanylhydrazone compounds are
also useful as inhibitors of deoxyhypusine synthase and as inhibitors for
nuclear export in infectious diseases and may be used to regulate
bacterially induced TNF-.alpha. production. Furthermore, the aromatic
guanylhydrazones exhibit antibacterial activity against Gram positive and
Gram negative bacteria and can be regarded as a novel class of
antibiotics. In addition, methods for prophylaxis and treatment of
virally or bacterially induced infections and diseases are disclosed
together with pharmaceutical compositions useful within said methods
containing at least one aromatic guanylhydrazone of the present invention
as active ingredient.
