A method for furnishing a therapeutic-agent-containing medical device is provided.
The method comprises: (a) providing a reactive layer comprising a cross-linking
agent on a medical device surface; and (b) subsequently applying a polymer-containing
layer, which comprises a polymer and a therapeutic agent, over the reactive layer.
The cross-linking agent interacts with the polymer to form a cross-linked polymeric
region that comprises the therapeutic agent. Examples of medical devices include
implantable or insertable medical devices, for example, catheters, balloon, cerebral
aneurysm filler coils, arterio-venous shunts and stents.
