According to the subject invention, dispersible dry powder pharmaceutical-based
compositions are provided, including methods for their manufacture and dry powder
dispersion devices. A dispersible dry powder pharmaceutical-based composition is
one having a moisture content of less than about 10% by weight (% w) water, usually
below about 5% w and preferably less than about 3% w; a particle size of about
1.0-5.0 m mass median diameter (MMD), usually 1.0-4.0 m MMD, and
preferably 1.0-3.0 m MMD; a delivered dose of about 30%, usually 40%,
preferably 50%, and most preferred 60%; and an aerosol particle size
distribution of about 1.0-5.0 m mass median aerodynamic diameter (MMAD),
usually 1.5-4.5 m MMAD, and preferably 1.5-4.0 m MMAD. Such compositions
are of pharmaceutical grade purity.
