The present invention provides a method of calibrating a spectroscopic device
for providing a non-invasive measurement of an analyte level in a sample. The method
comprises the steps of: (a) providing a plurality of calibration algorithms; (b)
taking a set of non-invasive measurements on said sample with said spectroscopic
device; (c) calculating a predicted set of analyte levels for each of the calibration
algorithms in response to the set of non-invasive measurements, each of the predicted
sets of analyte levels being characterized by a variability range, a slope, an
R (a square of the correlation between said set of non-invasive measurements
and said predicted set of analyte levels), and a standard error of prediction;
and (d) selecting an appropriate calibration algorithm by using a suitability score
based on the variability range, the slope, the R2 an the standard error
of prediction for each of the predicted sets of analyte levels. A method of generating
suitable calibration algorithms in step (a) is also provided.
