A vector system which can be incorporated in liposomes, comprising at least one
DNA vector, the vector or vectors containing a target-cleaving hammerhead ribozymal
DNA sequence under control of a promoter effective in human cells and which, upon
transcription to RNA will cleave the mRNA transcribed from a target gene encoding
the CCR5 or CXCR4 protein.
Preferably the ribozymal DNA contains a first recognition sequence (5
to 3):
- tagattg or ctcact, respectively for CCR5 or CXCR4 and downstream thereof
a second recognition sequence
- acttg or acgttgt respectively for CCR5 or CXCR4.
