Enhancers which preferentially increase the transcription of cis-linked
coding sequences in prostate cells are provided. Methods of using DNA constructs
comprising the enhancers to control transcription of heterologous polynucleotides
are also provided. Delivery vehicles comprising the enhancers and methods of using
the vehicles are also provided. Adenovirus vectors in which one or more genes are
under transcriptional control of the enhancers of the invention are also provided.
Further provided are methods of using the adenovirus vectors of the invention to
confer selective cytotoxicity in mammalian cells.
