Compositions and methods for improving cellular internalization of one
or more compounds are disclosed. The compositions include a compound to be delivered
and a biocompatible viscous material, such as a hydrogel, lipogel, or highly viscous
sol. The composition also include, or are administered in conjunction with, an
enhancer in an amount effective to maximize expression of or binding to receptors
and enhance RME of the compound into the cells. This leads to high transport rates
of compounds to be delivered across cell membranes, facilitating more efficient
delivery of drugs and diagnostic agents. Compositions are applied topically orally,
nasally, vaginally, rectally, and ocularly. The enhancer is administered with the
composition or separately, either systemically or preferably locally. The compound
to be delivered can also be the enhancer.
