Melanin concentrating hormone receptor ligands (especially substituted benzoimidazole
analogues), capable of modulating MCH receptor activity, are provided. Such ligands
may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are
particularly useful in the treatment of a variety of metabolic, feeding and sexual
disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical
compositions and methods for treating such disorders are provided, as are methods
for using such ligands for detecting MCH receptors (e.g., receptor localization studies).
