The present invention relates to novel Death Domain Containing Receptor-4 (DR4)
proteins which are members of the tumor necrosis factor (TNF) receptor family.
In particular, isolated nucleic acid molecules are provided encoding the human
DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and
recombinant methods for producing the same. The invention further relates to screening
methods for identifying agonists and antagonists of DR4 activity and methods for
using DR4 polynucleotides and polypeptides.
