Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing
hormone are described. Such compounds and their pharmaceutically acceptable salts,
prodrugs, and active metabolites are suitable for treating mammalian reproductive
disorders and steroid hormone-dependent tumors as well as for regulating fertility,
where suppression of gonadotropin release is indicated. Methods for synthesizing
the compounds and intermediates useful in their preparation are also described.
