A method for synthesizing electrocardiogram leads includes obtaining a sequence
of voltage-time measurements for a set of electrocardiogram leads and subjecting
the measurements to abstract factor analysis to obtain a set of eigenvalues and
associated eigenvectors. A minimal subset of electrocardiogram leads is identified
from which the voltage-time measurements can be calculated with acceptable error.
Simplex optimization is performed on a subset of the voltage-time measurements
measured with the minimal subset of electrocardiogram leads to obtain a universal
transformation matrix, and the universal transformation matrix is multiplied by
the subset of the voltage-time measurements to calculate the full set of voltage-time
measurements. The full set of leads can be used to calculate a body surface map,
and the eigenvalues can be tracked in time to predict the onset of pathology such
as myocardial infarction.
