A flexible applicator for applying an oil-in-water emulsion comprises: (1) an
allantoin-containing
oil-in-water emulsion; and (2) a flexible element that adsorbs or absorbs the emulsion
such that the emulsion is applied to the skin of a patient on whom the flexible
applicator is placed. The allantoin-containing emulsion, containing allantoin and
an emulsifier, has improved stability coming from the adjustment of the pH to a
range of 3.0 to 6.0; preferably, the pH is in the range of 4.5 to about 5.8. The
lower pH preserves the stability of the allantoin and the functionality of the
emulsifier system is maintained. The emulsifier system can be a nonionic emulsifier
or an anionic emulsifier plus beeswax. The acid used to adjust the pH can be an
organic acid or an inorganic acid. The emulsion can further comprise other ingredients
such as herbal extracts, chelating agents, preservatives, emollients, solvents,
and fragrance. The flexible element can be in the form of a bandage or wipe, and
can be formed of a material such as cotton, cellulose, nylon, rayon, a non-woven
fabric, or a plastic polymer.
