The invention relates to iRNA agents, which preferably include a monomer
in which the ribose moiety has been replaced by a moiety other than
ribose. The inclusion of such a monomer can allow for modulation of a
property of the iRNA agent into which it is incorporated, e.g., by using
the non-ribose moiety as a point to which a ligand or other entity, e.g.,
a lipophilic moiety. e.g., cholesterol, is is directly, or indirectly,
tethered. The invention also relates to methods of making and using such
modified iRNA agents.
