This invention provides populations of neural cells bearing markers of
glial cells, such as oligodendrocytes and their precursors. The
populations are generated by differentiating pluripotent stem cells such
as human embryonic stem cells under conditions that promote enrichment of
cells with the desired phenotype or functional capability. Various
combinations of differentiation factors and mitogens can be used to
produce cell populations bearing markers of oligodendrocyte precursor
cells. Upon further differentiation form complex processes characteristic
of mature oligodendrocytes. The cells are capable of forming myelin
sheaths, and can be used therapeutically improve function of the central
nervous system.
