A set of contiguous and partially overlapping cDNA sequences and polypeptides
encoded
thereby, designated as PS116 and transcribed from prostate tissue, is described.
These sequences are useful for the detecting, diagnosing, staging, monitoring,
prognosticating, in vivo imaging, preventing or treating, or determining the predisposition
of an individual to diseases and conditions of the prostate, such as prostate cancer.
Also provided are antibodies which specifically bind to PS116-encoded polypeptide
or protein, and agonists or inhibitors which prevent action of the tissue-specific
PS116 polypeptide, which molecules are useful for the therapeutic treatment of
prostate diseases, tumors or metastases.
