A method and composition for artificial insemination. The method involves artificially
inseminating the subject with sperm, wherein the sperm is combined or coadministered
with an inhibitor of phosphodiesterase and preferably a soluble salt of an earth
alkaline metal. The composition comprises phosphodiesterase inhibitor or a functional
equivalent thereof, a soluble salt of an earth alkaline metal and sperm. The method
and composition reduce the recruitment of polymorphonuclear neutrophils.
