Inhibitors of .alpha.4 mediated cell adhesion

   
   

The present invention relates to a pharmaceutical composition comprising as an active ingredient a compound of formula (I), wherein Ring A is an aromatic or a heterocyclic ring; Q is a bond, carbonyl, lower alkylene, lower alkenylene, --O-- -(lower alkylene)-, etc.; n is 0, 1 or 2; Z is oxygen or sulfur; W is oxygen, sulfur, --CH.dbd.CH--, --NH-- or --N.dbd.CH--; R.sup.1, R.sup.2 and R.sup.3 are the same or different and are hydrogen, halogen, hydroxyl, a substituted or unsubstituted lower alkyl gorup, a substituted or unsubstituted lower alkoxy group, a substituted or unsubstituted amino group, etc.; R.sup.4 is tetrazolyl, carboxyl group, amide or ester; R.sup.5 is hydrogen, nitro, amino, hydroxyl, lower alkanoyl, lower alkyl, etc.; R.sup.6 is selected from (a) a substituted or unsubstituted phenyl group, (b) a substituted or unsubstituted pyridyl group, (c) a substituted or unsubstituted thienyl group, (d) a substituted or unsubstituted benzofuranyl group, etc.; or a pharmaceutically acceptable salt thereof.

 
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