Solid dosage forms are produced by absorbing solutions of drug:cyclodextrin
inclusion complexes on absorbing matrices and then drying. The matrices may, but
need not, disintegrate in water. The resulting forms are suitable for oral or sublingual
administration, and also can be used in topical administrations to mucosa covered
tissues. They are particularly suitable for sublingual administration because the
eluted, nondisintegrated matrix (e.g., absorbing paper) can be recovered and checked
for completion of elution. This enables documentation that effective absorption
occurred from the mouth cavity.
