Antimicrobial activity of gemfibrozil and related compounds and derivatives and metabolites thereof

   
   

The present invention provides a method of selecting a compound which inhibits the enzymatic activity of enoyl reductase which comprises: (A) contacting enoyl reductase with the compound linked to an acyl carrier protein; (B) measuring the enzymatic activity of the enoyl reductase of step (A) compared with the enzymatic activity of enoyl reductase in the absence of the compound and selecting the compound which inhibits the enzymatic activity of enoyl reductase.

A invenção atual fornece um método de selecionar um composto que iniba a atividade enzymatic do reductase do enoyl que compreende: (A) contatando o reductase do enoyl com o composto ligou a uma proteína do portador do acyl; (B) medindo a atividade enzymatic do reductase do enoyl da etapa (A) comparou com a atividade enzymatic do reductase do enoyl na ausência do composto e de selecionar o composto que inibe a atividade enzymatic do reductase do enoyl.

 
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