Interaction of MHC Class II proteins with members of the PCNA family of proteins

   
   

Present invention based on the identification of the molecular interaction that forms the basis of the immunosuppressive activity of peptides comprising residues 71-80 of an MHC Class II protein (Class II peptides). Specifically the present invention discloses that Class II peptides bind to members of the PCNA family of proteins. Based on this observation, present invention provides methods for identifying agents that can be used to modulate immune system activity.

Invenção atual baseada na identificação da interação molecular que dá forma à base da atividade immunosuppressive dos peptides que compreendem resíduos 71-80 de uma proteína da classe II de MHC (peptides da classe II). Especificamente a invenção atual divulga que os peptides da classe II ligam aos membros da família de PCNA das proteínas. Baseado nesta observação, a invenção atual fornece métodos identificando os agentes que podem ser usados modular a atividade do sistema imune.

 
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