Combination of a cyclic hexapeptide with antifungal drugs for treatment of fungal pathogens

   
   

There is described antifungal combination use of known antifungal agents such as the azoles or polyenes in combination with a lipopeptide compound antifungal agent. More particularly, the invention relates to antifungal combination use of azols such as fluconazole voriconazole, itraconazole, ketoconazole, miconazole, ER 30346 and SCH 56592; polyenes such as amphotericin B, nystatin, liposomal and lipid forms thereof such as Abelcet, AmBisome and Amphocil; purine or pyrimidine nucleotide inhibitors such as flucytosine; or polyoxins such as nikkomycins, in particular nikkomycin Z or nikkomycin X; other chitin inhibitors; elongation factor inhibitors such as sordarin and analogs thereof; mannan inhibitors such as predamycin, bactericidal/permeability-inducing (BPI) protein products such as XMP.97 or XMP.127; or complex carbohydrate antifungal agents such as CAN-296; with a lipopeptide compound (I) as described herein.

Il y a utilisation antifongique décrite de combinaison des agents antifongiques connus tels que les azoles ou les polyenes en combination avec un agent antifongique de composé de lipopeptide. Plus en particulier, l'invention concerne l'utilisation antifongique de combinaison des azols tels que le voriconazole de fluconazole, itraconazole, ketoconazole, miconazole, HEU 30346 et SCH 56592 ; les polyenes tels que l'amphotéricine B, le nystatin, liposomique et lipide forme en comme Abelcet, AmBisome et Amphocil ; inhibiteurs de nucléotide de purine ou de pyrimidine tels que le flucytosine ; ou polyoxins tels que des nikkomycins, en particulier nikkomycin Z ou nikkomycin X ; d'autres inhibiteurs de chitine ; inhibiteurs de facteur d'élongation tels que le sordarin et les analogues en ; inhibiteurs de mannane tels que le predamycin, les produits de protéine de bactericidal/permeability-inducing (BPI) tels que XMP.97 ou le XMP.127 ; ou agents antifongiques d'hydrate de carbone complexe tels que CAN-296 ; avec un composé de lipopeptide (i) comme décrit ci-dessus.

 
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