Use

   
   

The present invention relates to a new use of oxindole derivatives of formula I, as a free base or pharmaceutically acceptable salts thereof, in the manufacture of a medicament for the prevention and/or treatment of dementia related diseases, Alzheimer's Disease and conditions associated with glycogen synthase kinase-3. Formula (I) wherein R.sup.1, R.sup.2, R.sup.3, ring Z, m and n are as defined as in claim 1. The present invention further relates to a method of prevention and/or treatment of dementia related diseases, Alzheimer's Disease and conditions associated with glycogen synthase kinase-3, as well as a pharmaceutical composition for said use. 1

A invenção atual relaciona-se a um uso novo de derivatives do oxindole da fórmula I, como uma base livre ou pharmaceutically uns sais aceitáveis disso, na manufatura de um medicament para a prevenção e/ou o tratamento das doenças relacionadas dementia, da doença de Alzheimer e das circunstâncias associadas com o synthase kinase-3 do glycogen. Fórmula (I) wherein R.sup.1, R.sup.2, R.sup.3, o anel Z, m e n são como definidos como na reivindicação 1. A invenção atual mais adicional relaciona-se a um método da prevenção e/ou ao tratamento das doenças relacionadas dementia, da doença de Alzheimer e das circunstâncias associadas com o synthase kinase-3 do glycogen, as.well.as uma composição pharmaceutical para uso dito. 1

 
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