Method of changing conformation of a matrix metalloproteinase

   
   

The present invention provides a matrix metalloproteinase inhibiting compound having structure (VIII) or a salt, an enantiomer, a diastereomer, a racemate, or a tautomer thereof. In other embodiments, the present invention provides a method of changing the conformation of a matrix metalloproteinase, a method of inhibiting a matrix metal metalloproteinase, and a method of treating osteoarthritis. ##STR1##

La presente invenzione fornisce un'inibizione di metalloproteinase della tabella compound avendo struttura (viii) o un sale, un enanziomero, un diastereomer, un racemate, o un tautomer di ciò. In altri incorporamenti, la presente invenzione fornisce un metodo di cambiare la conformazione di un metalloproteinase della tabella, un metodo di inibizione del metalloproteinase del metallo della tabella e un metodo di trattare la osteoartrite. ## del ## STR1

 
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