Antibody fragment-polymer conjugates and humanized anti-IL-8 monoclonal antibodies

   
   

Humanized anti-IL-8 monoclonal antibodies and variants thereof are described for use in diagnostic applications and in the treatment of inflammatory disorders. Also described is a conjugate formed by an antibody fragment covalently attached to a non-proteinaceous polymer, wherein the apparent size of the conjugate is at least about 500 kD. The conjugate exhibits substantially improved half-life, mean residence time, and/or clearance rate in circulation as compared to the underivatized parental antibody fragment.

Os antibodies anti-IL-8 monoclonal humanized e os variants disso são descritos para o uso em aplicações diagnósticas e no tratamento de disorders inflammatory. É descrito também um conjugate dado forma por um fragmento do antibody unido covalently a um polímero non-non-proteinaceous, wherein o tamanho aparente do conjugate é ao menos o kD aproximadamente 500. O conjugate exibe o half-life substancialmente melhorado, tempo de residência médio, e/ou a taxa de afastamento na circulação em comparação ao underivatized o fragmento parental do antibody.

 
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