Methods of treating diabetic cardiomyopathy using glycogen phosphorylase inhibitors

   
   

The present invention provides methods of treating diabetic cardiomyopathy, the methods comprising administering to a patient having or at risk of having diabetic cardiomyopathy a therapeutically effective amount of a glycogen phosphorylase inhibitor. The present invention also provides methods of treating diabetic cardiomyopathy, the methods comprising administering to a patient having 1) diabetes and 2) having cardiovascular disease, ischemic heart disease, congestive heart failure, congestive heart failure but not having coronary arteriosclerosis, hypertension, diastolic blood pressure abnormalities, microvascular diabetic complications, abnormal left ventricular function, myocardial fibrosis, abnormal cardiac function, pulmonary congestion, small vessel disease, small vessel disease without atherosclerotic cardiovascular disease or luminal narrowing, coagulopathy, cardiac contusion, or having had or at risk of having a myocardial infarction a therapeutically effective amount of a glycogen phosphorylase inhibitor.

A invenção atual fornece métodos de tratar o cardiomyopathy diabetic, os métodos que compreendem a administração a um paciente que tem ou no risco de ter o cardiomyopathy diabetic um uma quantidade therapeutically eficaz de um inibidor do phosphorylase do glycogen. A invenção atual fornece também métodos de tratar o cardiomyopathy diabetic, os métodos que compreendem a administração a um paciente que tem 1) o diabetes e 2) tendo a doença cardiovascular, a doença de coração isquêmica, a falha de coração congestive, a falha de coração congestive mas não estar com o arteriosclerosis coronary, hypertension, abnormalities diastolic da pressão de sangue, complicações diabetic microvascular, função ventricular esquerda anormal, fibrosis myocardial, função cardiac anormal, congestion pulmonary, doença pequena da embarcação, doença pequena da embarcação sem contusion estreitando-se, coagulopathy, cardiac atherosclerotic da doença cardiovascular ou do luminal, ou tendo ou no risco de ter um infarction myocardial um uma quantidade therapeutically eficaz de um inibidor do phosphorylase do glycogen.

 
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