2-Substituted benzimidazole piperidines analogs as selective melanin concentrating hormone receptor antagonists for the treatment of obesity and related disorders

   
   

The present invention discloses compounds of formula I 1 wherein Ar, Y, m, n, R.sup.1 and R.sup.4 are herein defined, said compounds being novel antagonists for melanin-concentrating hormone (MCH), as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such MCH antagonists as well as methods of using them to treat obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes.

La actual invención divulga compuestos del fórmula I 1 en donde Ar, Y, m, n, R.sup.1 y R.sup.4 adjunto se definen, compuestos dichos que son antagonistas de la novela para la hormona melanin-que se concentra (MCH), así como los métodos para preparar tales compuestos. En otra encarnación, la invención divulga las composiciones farmacéuticas que abarcan a tales antagonistas de MCH así como métodos de usarlos para tratar la obesidad, desórdenes metabólicos, comiendo desórdenes tales como hyperphagia, y la diabetes.

 
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