Regeneration and augmentation of bone using mesenchymal stem cells

   
   

Disclosed are compositions and methods for augmenting bone formation by administering isolated human mesenchymal stem cells (hMSCs) with a ceramic material or matrix or by administering hMSCs; fresh, whole marrow; or combinations thereof in a resorbable biopolymer which supports their differentiation into the osteogenic lineage. Contemplated is the delivery of (i) isolated, culture-expanded, human mesenchymal stem cells; (ii) freshly aspirated bone marrow; or (iii) their combination in a carrier material or matrix.

São divulgados as composições e os métodos para aumentar a formação do osso administrando pilhas de haste mesenchymal humanas isoladas (hMSCs) com um material ou uma matriz cerâmica ou administrando hMSCs; marrow fresco, inteiro; ou combinações disso em um biopolymer resorbable que suporte seu differentiation no lineage osteogenic. É contemplada a entrega (i) do isolada, pilhas de haste mesenchymal cultura-expandidas, humanas; (ii) marrow de osso recentemente aspirated; ou (iii) sua combinação em um material ou em uma matriz do portador.

 
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