Proteases producing an altered immunological response and methods of making and using the same

   
   

The present invention provides novel protein variants that exhibit reduced immunogenic responses, as compared to the parental proteins. The present invention further provides DNA molecules that encode novel variants, host cells comprising DNA encoding novel variants, as well as methods for making proteins less allergenic. In addition, the present invention provides various compositions that comprise these proteins that are less immunogenic than the wild-type proteins.

A invenção atual fornece variants da proteína da novela que a exibição reduziu respostas immunogenic, em comparação às proteínas parental. A invenção atual mais adicional fornece as moléculas que codificam variants da novela, pilhas do DNA de anfitrião que compreendem variants codificando da novela do DNA, as.well.as métodos fazendo proteínas mais menos allergenic. Além, a invenção atual fornece as várias composições que compreendem estas proteínas que são mais menos immunogenic do que o selvagem-tipo proteínas.

 
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< Novel substance having physiological property, method for producing the same and uses thereof

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> Thymosin augmentation of genetic immunization

> Method for generating influenza viruses and vaccines

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