Phenyl naphthol ligands for thyroid hormone receptor

   
   

New thyroid receptor ligands are provided which have the general formula I 1 wherein R.sub.1 is halogen, trifluoromethyl, substituted or unsubstituted aryl, substituted or unsubstituted C.sub.1-6 alkyl, or substituted or unsubstituted C.sub.3-7 cycloalkyl; R.sub.2 and R.sub.3 are each independently hydrogen, halogen, substituted or unsubstituted C.sub.1-4 alkyl, or substituted or unsubstituted C.sub.3-6 cycloalkyl, wherein at least one of R.sub.2 and R.sub.3 is other than hydrogen; R.sub.4 is a carboxylic acid selected from the group consisting of (CH.sub.2).sub.nCOOH, (CH).sub.2COOH, NHCO(CH.sub.2).sub.nCOOH, CONH(CH.sub.2).sub.nCOOH and NH(CH.sub.2).sub.mCOOH; n is an integer from 0 to 4; and m is an integer from 1 to 4. In addition, a method is provided for preventing, inhibiting or treating a disease associated with metabolism dysfunction or which is dependent upon the expression of a T.sub.3 regulated gene, wherein a compound as described above is administered in a therapeutically effective amount.

 
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