Novel antiviral combinations for the treatment or prevention of viral
infections, in particular, HIV, are disclosed. This new antiviral therapy
employs either DP-178 or DP-107, viral fusion inhibitors, in combination
with at least one other antiviral therapeutic agent. The combinations of
the invention are better than single therapies alone, and in certain cases
are synergistic. The use of DP-178 or DP-107 is an ideal therapy to
combine with another antiviral, given both the novel mechanism which this
therapeutic blocks HIV transmission and the non-toxicity of the
therapeutic.
