Nucleosidic and non-nucleosidic folate conjugates

   
   

Oligonucleotide-folate conjugates are described wherein folates are conjugated to one or more sites on an oligonucleotide including the 2'-, 3'-, 5'-, nucleobase and internucleotide linkage sites. The folate can be attached via the .alpha.- or .gamma.-carboxylate, optionally through a linking group. Methods for the regiospecific synthesis of the conjugates are disclosed. Also disclosed are nucleosidic and non-nucleosidic linkers conjugated to folic acid and related folates.

описаны Олигонуклеотид-oligonucleotide-folate конъюгаты при котором folates проспряганы к one or more местам на олигонуклеотиде включая 2' -, 3' -, 5' -, nucleobase и места рычага internucleotide. Folate можно прикрепиться через alpha. - или gamma.-karboksilat, опционно через соединяя группу. Показаны методы для regiospecific синтеза конъюгатов. Также показаны nucleosidic и non-nucleosidic линкеры проспряганные к фолиевой кислоте и отнесенным folates.

 
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