The present invention relates to inhibitors of the transcription factor
STAT-1, their use as therapeutic means as well as their use for the
prevention or therapy of cardio-vascular complications like restenosis
after percutaneous angioplasty or stenosis of venous bypasses, the graft
versus host reaction, the ischemia/refusion-related damage in the context
of surgical interventions and organ transplantation respectively,
immunological hypersensitivity reactions, in particular the allergic
rhinitis, the drug and food allergies, in particular urticaria and celiac
disease (sprue), contact eczema and the immune complex diseases, in
particular alveolitis, arthritis, glomerulonephritis and allergic
vasculitis, inflammatory chondro- and osteopathies, in particular
arthrosis, gout, ostitis and osteomyelitis, polyneuritis as well as acute
and subacute respectively, infection contingent and in particular
post-infectious inflammatory diseases, in particular bronchitis,
endocarditis, hepatitis, myocarditis, nephritis, pericarditis,
peritonitis and pancreatitis, including the septic shock.
De onderhavige uitvinding heeft respectievelijk op inhibitors van transcriptiefactor stat-1, hun gebruik als therapeutische middelen evenals hun gebruik voor de preventie of de therapie van cardiovasculaire complicaties zoals restenosis na percutane angioplasty of vernauwing van aderlijke omleidingen, ent tegenover gastheerreactie, de ischemie/de op refusion betrekking hebbende schade in de context van chirurgische acties en orgaanoverplanting, de immunologische hypergevoeligheidsreacties, in het bijzonder het allergische Rhinitis, de drug en voedselallergieën, in het bijzonder urticaria en de ziekte van de buikholte (sprue), contacteczema en de immuun complexziekten, in het bijzonder alveolitis, artritis, glomerulonephritis en allergische vasculitis, ontstekingschondro - en osteopathie, in het bijzonder artrose betrekking, gout, ostitis rapeutic means as well as their use for the prevention or therapy of cardio-vascular complications like restenosis after percutaneous angioplasty or stenosis of venous bypasses, the graft versus host reaction, the ischemia/refusion-related damage in the context of surgical interventions and organ transplantation respectively, immunological hypersensitivity reactions, in particular the allergic rhinitis, the drug and food allergies, in particular urticaria and celiac disease (sprue), contact eczema and the immune complex diseases, in particular alveolitis, arthritis, glomerulonephritis and allergic vasculitis, inflammatory chondro - and osteopathies, in particular arthrosis, gout, ostitis and osteomyelitis, polyneuritis as well as acute and subacute respectively, infection contingent and in particular post-infectious inflammatory diseases, in het bijzonder bronchitis, endocarditis, hepatitis, myocarditis, nefritis, pericarditis, peritonitis en pancreatitis, met inbegrip van de septische schok.
