Spiro[isobenzofuran-1,4'-piperidin]-3-ones and 3h-spiroisobenzofuran-1,4'-- piperidines

   
   

Substituted spiro[isobenzofuran-1,4'-piperidin]-3-ones and 3H-spiroisobenzofuran-1,4'-piperidines capable of modulating NPY5 receptor activity are provided. Such compounds may be used to modulate ligand binding to NPY5 receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of disorders (e.g., eating disorders such as obesity or bulimia, psychiatric disorders, diabetes and cardiovascular disorders such as hypertension) in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and method for treating such disorders are provided, as are methods for using such compounds for detecting NPY5 receptors.

Spiro[isobenzofuran-1,4'-piperidin]-3-ones substituídos e 3H-spiroisobenzofuran-1,4'-piperidines capazes de modular a atividade do receptor NPY5 são fornecidos. Tais compostos podem ser usados modular o ligand que liga aos receptors NPY5 em vivo ou em vitro, e são particularmente úteis no tratamento de uma variedade dos disorders (por exemplo, comendo disorders tais como o obesity ou o bulimia, disorders psychiatric, diabetes e disorders cardiovascular tais como o hypertension) nos seres humanos, domesticated animais do companheiro e animais dos animais domésticos. As composições e o método pharmaceutical para tratar tais disorders são fornecidos, como são métodos para usar tais compostos para detectar os receptors NPY5.

 
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