HIV protease inhibitors

   
   

The present invention relates to novel dihydropyrones with tethered heterocycles having improved pharmacologic properties which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The dihydropyrones are useful in the development of therapies for the treatment of viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of the dihydropyrones and intermediates useful in the preparation of the final compounds.

De onderhavige uitvinding heeft op nieuwe dihydropyrones met gebonden heterocycles farmacologische eigenschappen betrekking verbeterd te hebben die krachtig de HIV aspartylprotease verbieden die HIV besmettelijkheid blokkeert. Dihydropyrones zijn nuttig in de ontwikkeling van therapie voor de behandeling van virale besmettingen en ziekten, met inbegrip van AIDS. De onderhavige uitvinding wordt ook geleid aan methodes van synthese van dihydropyrones en de tussenpersonen nuttig in de voorbereiding van de definitieve samenstellingen.

 
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