3,7-dihydro-purine-2,6-dione derivatives as CRF receptor ligands

   
   

Compounds provided herein are 3,7-dihydro-purine-2,6-dione derivatives of Formula (I): 1 Such compounds are particularly useful as CRF receptor ligands, and hence, in the treatment of various neurologically-related disorders such as affective disorder, anxiety and depression, headache, irritable bowel syndrome, post-traumatic stress disorder, supranuclear palsy, immune suppression, Alzheimer's disease, gastrointestinal diseases, anorexia nervosa or other feeding disorder, drug addiction, drug or alcohol withdrawal symptoms, inflammatory diseases, cardiovascular or heart-related diseases, fertility problems, human immunodeficiency virus infections, hemorrhagic stress, obesity, infertility, head and spinal cord traumas, epilepsy, stroke, ulcers, amyotrophic lateral sclerosis or hypoglycemia.

Hierin verstrekte de samenstellingen zijn 3.7-dihydro-purine-2.6-dionederivaten van Formule (I): 1 Dergelijke samenstellingen zijn bijzonder nuttig als receptor CRF ligands, en vandaar, in de behandeling van diverse op neurologisch betrekking hebbende wanorde zoals affectieve wanorde, bezorgdheid en depressie, hoofdpijn, irritable darmsyndroom, post-traumatische spanningswanorde, supranuclear verlamming, immune afschaffing, de ziekte van Alzheimer, gastro-intestinale ziekten, anorexia nervosa of andere het voeden wanorde, drugverslaving, drug of alcoholterugtrekkingssymptomen, ontstekingsziekten, cardiovasculaire of op hart betrekking hebbende ziekten, vruchtbaarheidsproblemen, menselijke immunodeficiency virusbesmettingen, hemorrhagic spanning, zwaarlijvigheid, onvruchtbaarheid, hoofd en ruggemergtrauma's, epilepsie, slag, zweren, amyotrophic zijsclerose of hypoglycemia.

 
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