Process for preparing rac-bicalutamide and its intermediates

   
   

The present invention relates to a new process for the synthesis of racemic and optically active bicalutamide starting from ethyl pyruvate and methyl methacrylate. The present invention discloses processes of preparing bicalutamide intermediates including ethyl-[2-{4-fluorophenyl sulfone)]-2-hydroxy propionate, 1,2-epoxy-2-methyl propionate and 2-hydrox-2-methyl-3-(4-fluorophenylthio) propionic acid. The present invention further discloses micronized rac-bicalutamide and the preparation thereof.

La presente invenzione riguarda un nuovo processo per la sintesi del bicalutamide racemico ed otticamente attivo a partire da piruvato etilico e da metacrilato metilico. La presente invenzione rileva i processi di preparazione degli intermediari di bicalutamide compreso il proponiato di ethyl-[2-{4-fluorophenyl sulfone)]-2-hydroxy, il proponiato 1,2-epoxy-2-methyl e l'acido propionico 2-hydrox-2-metilico-3-(4-fluorophenylthio). La presente invenzione ulteriore rileva il rac-bicalutamide micronizzato e la preparazione di ciĆ².

 
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