The invention relates to an MDR family P-glycoprotein located on human
chromosome 7p15-21, polynucleotide sequences encoding this P-glycoprotein
and fragments thereof. This gene is utilized in methods for assessing
cancer cell susceptibility to therapies directed against multidrug
resistance, and for the design of diagnostic and therapeutic methods
relating to cancer multidrug resistance. The invention also relates to
methods for determining whether a test compound may inhibit multidrug
resistance.
