Methods and molecules useful for identifying molecules that bind LFA-1 and for determining receptor occupancy

   
   

The present invention relates generally to a method for identifying molecules that bind the R7.1 epitope of LFA-1 or bind LFA-1 such that the R7.1 epitope is modified. The present invention further relates to a method for determining occupancy of the LFA-1 receptor by molecules that bind to the R7.1 epitope or bind LFA-1 such that the R7.1 epitope is modified after administration to a subject. The present invention further relates to molecules useful in the methods of the invention.

De onderhavige uitvinding heeft over het algemeen op een methode om molecules betrekking te identificeren die R7.1 epitope van lfa-1 binden of lfa-1 binden dusdanig dat R7.1 epitope wordt gewijzigd. De onderhavige uitvinding heeft verder op een methode om inbezitneming van de lfa-1 receptor door molecules betrekking te bepalen die aan R7.1 epitope binden of lfa-1 binden dusdanig dat R7.1 epitope na beleid aan een onderwerp wordt gewijzigd. De onderhavige uitvinding heeft verder op molecules nuttig in de methodes van de uitvinding betrekking.

 
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